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Risk of Trastuzumab-Related Cardiotoxicity in Early Breast Cancer Patients: A Prospective Observational Study.

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In performing the lyophilization, the lyophilization conditions are controlled so that the cyclophosphamide is precipitated as a hydrated polymorph and then the process is completed under conditions which are carefully selected so that water bound to the cyclophosphamide as the monohydrate is not removed during the remainder of the lyophilization process.

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We report here on the use of CyBorD as initial therapy before autologous stem cell transplantation (ASCT), as an alternative to high-dose therapy for those deemed ineligible, and as salvage for those with prior therapy.

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